Matsuzaki, T., Matsumoto, S., Kasai, T., Yoshizawa, E., Okamoto, S., Yoshikawa, H. Y., Taniguchi, H., Takebe, T.* (2018). Defining lineage-specific membrane fluidity signatures that regulate adhesion kinetics. Stem Cell Reports PDF

Image of this Article

Image of this Article
Painted a scene of membrane fluidity regulated by catechin,
and adhesion sorting.
Direction: Takahisa, Takanrori
Design: Asuka


Ayabe, H., Anada, T., Kaomoya, T., Sato, T., Kimura M., Yoshizawa, E., Kikuchi, Shunyuu,. Ueno, Y., Sekine, K., Camp, J. G., Treutlein, B., Ferguson, A., Suzuki, O., Takebe, T.*, Taniguchi, H.* (2018). Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling. Stem Cell Reports 2, 11 PDF


Kimura, M., Azuma, M., Zhang, R.R., Thompson, W., Mayhew, C.N., Takebe, T.* (2018). Digitalized Human Organoid for Wireless Phenotyping. iScience 5, 007 PDF
Featured in Cell Press
Featured in Chemical & Engineering News

Takahashi, Y., Sekine, K., Kin, T., Takebe, T.*, Taniguchi, H.* (2018). Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation Cell Reports 23, 1620–1629 PDF


Cell Reports cover

Selected as Cover Article
This image shows blood vessels seven days after
transplantation of vascularized pancreatic islets into a mouse
and visualized by Texas red dextran, in white.
The tissue is highly vascularized
and has hormone-secreting capacity.


Zhang, R.R., Koido, M., Tadokoro, T., Ouchi, R., Matsuno, T., Ueno, Y., Sekine, K., Takebe, T.*, Taniguchi, H.* (2018). Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids. Stem Cell Reports 10, 780-793 PDF


Stem Cell Reports_cover

Image of This Article;
Illustration Described Reproducing Gut and Liver Organoids from PGEC
Designed by Asuka


Kagimoto, S., Takebe, T.*, Kobayashi, S., Yabuki, Y., Hori, A., Hirotomi, K., Mikami, T., Uemura, T., Maegawa, J., and Taniguchi, H. (2016). Autotransplantation of Monkey Ear Perichondrium-Derived Progenitor Cells for Cartilage Reconstruction. Cell Transplantation 25, 951-962.


Takebe, T.*, Enomura, M., Yoshizawa, E., Kimura, M., Koike, H., Ueno, Y., Matsuzaki, T., Yamazaki, T., Toyohara, T., Osafune, K., et al. (2015). Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation. Cell stem cell 16, 556-565.



Selected as Cover Article
Best of Cell Stem Cell, 2015
News and Views in Cell Stem Cell
Featured in Nature Methods


Takebe, T.*, Kobayashi, S., Suzuki, H., Mizuno, M., Chang, Y.M., Yoshizawa, E., Kimura, M., Hori, A., Asano, J., Maegawa, J., et al. (2014). Transient vascularization of transplanted human adult–derived progenitors promotes self-organizing cartilage. Journal of Clinical Investigation 124, 4325-4334.


Zheng, Y.W., Tsuchida, T., Shimao, T., Li, B., Takebe, T., Zhang, R.R., Sakurai, Y., Ueno, Y., Sekine, K., Ishibashi, N., et al. (2014). The CD133 + CD44 + Precancerous Subpopulation of Oval Cells Is a Therapeutic Target for Hepatocellular Carcinoma. Stem Cells and Development 23, 2237-2249.


Takebe, T.*, Zhang, R.R., Koike, H., Kimura, M., Yoshizawa, E., Enomura, M., Koike, N., Sekine, K., and Taniguchi, H. (2014). Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature Protocols 9, 396-409.


Takebe, T.*, Koike, N., Sekine, K., Fujiwara, R., Amiya, T., Zheng, Y.W., and Taniguchi, H. (2014). Engineering of human hepatic tissue with functional vascular networks. Organogenesis 10, 260-267.


Mizuno, M., Kobayashi, S., Takebe, T., Kan, H., Yabuki, Y., Matsuzaki, T., Yoshikawa, H.Y., Nakabayashi, S., Ik, L.J., Maegawa, J., et al. (2014). Brief Report: Reconstruction of Joint Hyaline Cartilage by Autologous Progenitor Cells Derived from Ear Elastic Cartilage. STEM CELLS 32, 816-821.


Koike, H., Ueno, Y., Naito, T., Shiina, T., Nakata, S., Ouchi, R., Obana, Y., Sekine, K., Zheng, Y.W., Takebe, T., et al. (2014). Ring1B promotes hepatic stem/progenitor cell expansion through simultaneous suppression of Cdkn1a and Cdkn2a in mice. Hepatology 60, 323-333.


Takebe, T.*, Sekine, K., Enomura, M., Koike, H., Kimura, M., Ogaeri, T., Zhang, R.R., Ueno, Y., Zheng, Y.W., Koike, N., et al. (2013). Vascularized and functional human liver from an iPSC-derived organ bud transplant. Nature 499, 481-484.


Selected as Breakthrough of the Year, 2013 in Science

Selected as World top 5 discovery in Discover magazine

News and Views in Nature

Featured in Science, Nature Medicine, Cell Stem Cell, Hepatology, Gastroenterology, Cell Research, etc…

Press in BBC, The Economist, Scientific American, The Guardian, etc…


Tanaka, H., Tanaka, S., Sekine, K., Kita, S., Okamura, A., Takebe, T., Zheng, Y.W., Ueno, Y., Tanaka, J., and Taniguchi, H. (2013). The generation of pancreatic β-cell spheroids in a simulated microgravity culture system. Biomaterials 34, 5785-5791.


Takebe, T.*, Sekine, K., Suzuki, Y., Enomura, M., Tanaka, S., Ueno, Y., Zheng, Y.W., and Taniguchi, H. (2012). Self-Organization of Human Hepatic Organoid by Recapitulating Organogenesis In Vitro. Transplantation Proceedings 44, 1018-1020.


Takebe, T.*, Koike, N., Sekine, K., Enomura, M., Chiba, Y., Ueno, Y., Zheng, Y.W., and Taniguchi, H. (2012). Generation of Functional Human Vascular Network. Transplantation Proceedings 44, 1130-1133.


Koike, H., Kubota, K., Sekine, K., Takebe, T., Ouchi, R., Zheng, Y.W., Ueno, Y., Tanigawa, N., and Taniguchi, H. (2012). Establishment of automated culture system for murine induced pluripotent stem cells. BMC Biotechnology 12, 81-81.


Kobayashi, S. #, Takebe, T. #, Zheng, Y.W., Mizuno, M., Yabuki, Y., Maegawa, J., and Taniguchi, H. (2011). Presence of Cartilage Stem/Progenitor Cells in Adult Mice Auricular Perichondrium. PLoS ONE 6, e26393-e26393.


Kobayashi, S. #, Takebe, T. #, Inui, M., Iwai, S., Kan, H., Zheng, Y.W., Maegawa, J., and Taniguchi, H. (2011). Reconstruction of human elastic cartilage by a CD44+ CD90+ stem cell in the ear perichondrium. Proceedings of the National Academy of Sciences 108, 14479-14484.


Takebe, T., Wells, J.M. (2019). Organoids by design. Science.

Takanori Takebe (2019) Experimental Medicine extra issue, Japan, Yodosha Co., Ltd.

Takebe, T.,* Wells, J.M., Helmrath, M.A., Zorn, A.M.* (2018). Organoid Center Strategies for Accelerating Clinical Translation.

Lewis K., Takebe, T.* (2018). Tumoroid à la carte: Path for personalization. Hepatology.

Takanori Takebe (2017) Experimental Medicine, Japan, Yodosha Co., Ltd.

Takahashi, Y., Takebe, T.*, and Taniguchi, H. (2016). Engineering pancreatic tissues from stem cells towards therapy. Regenerative Therapy 3, 15-23.

Shinozawa, T., Yoshikawa, H.Y., and Takebe, T*. (2016). Reverse engineering liver buds through self-driven condensation and organization towards medical application. Developmental Biology.

Koike H, Takebe T*. (2016) Generating Mini-Organs in Culture. Current Pathobiology Reports; doi:10.1007/s40139-016-0101-y.

Koike H, Takebe T*. Growing Mini-Organs from Stem Cells. Encyclopedia of Molecular Cell Biology and Molecular Medicine, Wiley-VCH, 2016.

Zhang, R.R., Koike, H., and Takebe, T.*(2015). The visualization of human organogenesis from stem cells by recapitulating multicellular interactions. In Hyper Bio Assembler for 3D Cellular Systems, pp. 275-283.

Taniguchi, H., and Takebe, T.* (2015). Generation of functional human organs from pluripotent stem cells. Japanese Journal of Transplantation 50, 24-30.

Rashid, T., Takebe, T., and Nakauchi, H. (2015). Novel strategies for liver therapy using stem cells. Gut 64, 1-4.

Takebe, T.*, and Taniguchi, H. (2014). Vascularized and functional liver deribed from human induced pluripotent stem cells by recapitulating organogenesis. Yokohama Medical Journal 65, 503-507.

Takebe, T.*, and Taniguchi, H. (2014). Human iPSC-derived miniature organs: a tool for drug studies. Clin Pharmacol Ther 96, 310-313.

Takahashi, Y., Takebe, T.*, and Taniguchi, H. (2014). Generation of pancreatic beta-cells from pluripotent stem cells. Organ Biology 21, 228-236.

Takebe, T.*, and Taniguchi, H. (2013). Creation of vascularized and functional organ from human iPS cell. Organ Biology 20, 182-185.

Judee Grace Nemeno-Guanzon, Johan Robert Berg, Mitsuru Mizuno, Soojung Lee, Yong Hwa Jo, Jee Eun Yeo, Bo Mi Nam, Bo Young Kim, Dae-Hyun Kim, Yong-Gon Koh, Takebe T* and JeongIk Lee*: Towards the advancement of blood vessel tissue engineering. International Journal of Tissue Regeneration, 4(1), 7-11, 2013.

Takanori Takebe: Creativity for a cure, Nature Medicine, 2019

Takanori Takebe: Advances in Organoid Technology: Hans Clevers, Madeline Lancaster, and Takanori Takebe, Q&A, Cell Stem Cell, 2017

Cassandra Willyard: ‘RISE OF THE ORGANOIDS’, Nature, 2015

David Cyranoski: Rudimentary liver grown in vitro, Nature, news & views, 2012