ARTICLE
2023
Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells
Cell | 27 October
We report a production protocol that overcomes these hurdles and that allows for mass production of HPCs from hiPSCs via the induction of yolk sac-like organoids without addition of exogenous factors.
Tamaoki N, Siebert S, Maeda T, Ha NH, Good ML, Huang Y, Vodnala SK, Haro-Mora JJ, Uchida N, Tisdale JF, Sweeney CL, Choi U, Brault J, Koontz S, Malech HL, Yamazaki Y, Isonaka R, Goldstein DS, Kimura M, Takebe T, Zou J, Stroncek DF, Robey PG, Kruhlak MJ, Restifo NP, Vizcardo R
Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19
Cell Stem Cell | 05 October
We developed an infection-competent human vascular organoid from pluripotent stem cells for modeling endotheliopathy. Longitudinal serum proteome analysis identified aberrant complement signature in critically ill patients driven by the amplification cycle regulated by complement factor B and D (CFD).
Kawakami E, Saiki N, Yoneyama Y, Takayama K, Nio Y, Takebe T
Preparation of mechanically patterned hydrogels for controlling the self-condensation of cells
STAR protocols | 28 July
We present a protocol for preparing hydrogels with mechanical patterns. We describe steps for hydrogel synthesis, mechanical evaluation of the substrate, and time-lapse imaging of cell self-organization.
Matsuzaki T, Kawano Y, Horikiri M, Shimokawa Y, Yamazaki T, Okuma N, Koike H, Kimura M, Kawamura R, Yoneyama Y, Furuichi Y, Hakuno F, Takahashi SI, Nakabayashi S, Okamoto S, Nakauchi H, Taniguchi H, Takebe T, Yoshikawa HY.
2022
En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH
Cell | 27 October
We devised a pooled human organoid-panel of steatohepatitis to investigate the impact of metabolic status on genotype-phenotype association.
Kimura M, Iguchi T, Iwasawa K, Dunn A, Thompson W, Yoneyama Y, Chaturvedi P, Zorn A, Wintzinger M, Quattrocelli M, Watanabe-Chailland M, Zhu G, Fujimoto M, Kumbaji M, Kodaka A, Gindin Y, Chung C, Myers R, Subramanian G, Hwa V, Takebe T
Mechanical guidance of self-condensation patterns of differentiating progeny
iScience | 27 September
We have developed a mechanically patterned hydrogel for controlling self-condensation process to generate multi-cellular organoids.
Matsuzaki T, Shimokawa Y, Koike H, Kimura M, Kawano Y, Okuma N, Kawamura R, Yoneyama Y, Furuichi Y, Hakuno F, Takahashi S, Nakabayashi S, Okamoto S, Nakauchi H, Taniguchi H, Takebe T, Yoshikawa H
Cell membrane fluidity and ROS resistance define DMSO tolerance of cryopreserved synovial MSCs and HUVECs
Stem cell research & therapy | 03 May
This study aimed to identify the biological and physical factors involved in the differences in freeze–thaw tolerance between MSCs and HUVECs.
Mizuno M, Matsuzaki T, Ozeki N, Katano H, Koga H, Takebe T, Yoshikawa HY & Sekiya I
Eicosatetraynoic Acid and Butyrate Regulate Human Intestinal Organoid Mitochondrial and Extracellular Matrix Pathways Implicated in Crohn’s Disease Strictures
Inflammatory Bowel Diseases | 08 March
We developed a patient-specific human intestinal organoid (HIO) model system to test small molecule regulation of mitochondrial and wound-healing functions implicated in stricturing behavior.
Ingrid Jurickova et al
Enteral liquid ventilation oxygenates a hypoxic pig model
iScience | 13 February
We assessed the enteral ventilation approach in hypoxic porcine models under controlled mechanical ventilation.
Fujii T, Yoneyama Y, Kinebuchi A, Ozeki N, Maeda S, Saiki N, Fengshi Chen-Yoshikawa T.F., Date H, Nishiwaki K, Takebe T
Correction of a Factor VIII genomic inversion with designer-recombinases
Nature Communications | 20 January
In this work, Lansing et al. present designer-recombinases as an efficient and specific means towards treatment of monogenic diseases caused by large gene inversions.
Lansing F, Mukhametzyanova L, Rojo-Romanos T. et al.
2021
Synthesis and application of POLYseq for profiling human liver organoids
STAR Protocols | 24 December
Dunn et al. updated the protocol for POLYseq using inexpensive, commercially available reagents.
Dunn A, Cai Y, Iwasawa K, Kimura M, Takebe T
Isolation and Characterization of Tissue Resident CD29-Positive Progenitor Cells in Livestock to Generate a Three-Dimensional Meat
Cells | 21 September
Naraoka et al. screened 246 cell-surface antibodies by fluorescence-activated cell sorting for their capacity to form colonies and their suitability to construct spheroid “meat buds”.
Naraoka Y, Mabuchi Y, Yoneyama Y, Suto EG, Hisamatsu D, Ikeda M, Ito R, Nakamura T, Takebe T, Akazawa C
POLYseq: A poly(β-amino ester)-based vector for multifunctional cellular barcoding
Stem Cell Reports | 26 August
Dunn et al. developed a novel poly(β-amino) ester labeling system synthesized with inexpensive, common reagents, termed POLYseq, capable of efficiently delivering fluorescent molecules or sample-distinguishing DNA barcodes through non-covalent binding enabling rapid creation of custom sample pools.
Andrew Dunn, Yuqi Cai, Kentaro Iwasawa, Masaki Kimura, Takanori Takebe.
Mammalian enteral ventilation ameliorates respiratory failure
Med | 14 May
Okabe el al. showed the effectiveness of an enteral ventilation approach in attaining systemic oxygenation in both rodent and porcine models, inspired by organisms such as loaches that use intestinal air breathing.
Ryo Okabe, Toyofumi F. Chen-Yoshikawa, Yosuke Yoneyama. Eiji Kobayashi, Hiroshi Date, Takanori Takebe.
Selected as Cover Article
Highlighted in Med Viewpoint, NYTimes, Economist, Science, Smithsonian Magazine, NYPost, National Geographic, TrontoStar the others.
Watch the video
Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection
Stem Cell Reports | 09 March
Dobrindt et al. applied human induced pluripotent stem cell (hiPSC)-based models and CRISPR engineering to explore the host genetics of SARS-CoV-2.
Dobrindt K, Hoagland DA, Seah C, Kassim B, O’Shea CP, Murphy A, Iskhakova M, Fernando MB, Powell SK, Deans PJM, Javidfar B, Peter C, Møller R, Uhl SA, Garcia MF, Kimura M, Iwasawa K, Crary JF, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ
Modeling Human Bile Acid Transport and Synthesis in Stem Cell-Derived Hepatocytes with a Patient-Specific Mutation
Stem Cell Reports | 09 February
Hayashi el al. developed a human induced pluripotent stem cell-based model of isogenic BSEP-deficient hepatocytes in a Transwell culture system.
Hayashi H, Osaka S, Sakabe K, Fukami A, Kishimoto E, Aihara E, Sabu Y, Mizutani A, Kusuhara H, Naritaka N, Zhang W, Huppert SS, Sakabe M, Nakamura T, Hu YC, Mayhew C, Setchell K, Takebe T, Asai A
Engineering human hepato-biliary-pancreatic organoids from pluripotent stem cells
Nature Protocol | 11 January
Koike et al. describe a protocol for the continuous patterning of hepatic, biliary and pancreatic (HBP) structures from a 3D culture of human pluripotent stem cells (PSCs).
Koike H, Iwasawa K, Ouchi R, Maezawa M, Kimura M, Kodaka A, Nishii S, Thompson WL, Takebe T
Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells
Nature Communications | 04 January
Fang et al. developed a new turn-on Zn2+ fluorescent probe, NapBu-BPEA, to ensure SIM imaging quality for organelle identification.
Fang H, Geng S, Hao M, Chen Q, Liu M, Liu C, Tian Z, Wang C, Takebe T, Guan JL, Chen Y, Guo Z, He W, Diao J
Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from human induced pluripotent stem cells
bioRxiv | 01 January
Tamaoki et al. showed that hiPSCs co-cultured with various types of stromal cells as spheroids self-organize into yolk sac-like organoids without the addition of exogenous factors.
Tamaoki N, Siebert S, Maeda T, Ngoc-H Ha, Good M L, Huang Y, Vodnala S K, Haro-Mora J J, Uchida N, Tisdale J F, Sweeney C L, Choi U, Brault J, Koontz S, Malech H L, Yamazaki Y, Isonaka R, Goldstein D S, Kimura M, Takebe T, Zou J, Stroncek D F, Robey P G, Kruhlak M J, Restifo N P, Vizcardo R
2020
Generation of human induced pluripotent stem cell-derived liver buds with chemically defined and animal origin-free media
Scientific reports | 21 October
CD-AOF media and supplements ensure the quality and reproducibility of culture systems. This protocol will facilitate the clinical applicability of all iPSC-LBs in the treatment of liver diseases.
Sekine K, Ogawa S, Tsuzuki S, Kobayashi T, Ikeda K, Nakanishi N, Takeuchi K, Kanai E, Otake Y, Okamoto S, Kobayashi T, Takebe T, Taniguchi H
Polygenic architecture informs potential vulnerability to drug-induced liver injury
Nature Medicine | 07 September
Koido et al. revealed genetically defined hepatocyte vulnerability mechanisms to currently unpredictable drug induced liver injury supported by cell-, organoid- and patient-level datasets.
Masaru Koido, Eri Kawakami, Junko Fukumura, Yui Noguchi, Momoko Ohori, Yasunori Nio, Paola Nicoletti, Guruprasad P Aithal, Ann K Daly, Paul B Watkins, Hisashi Anayama, Yvonne Dragan, Tadahiro Shinozawa, Takanori Takebe
Stiffness distribution analysis in indentation depth direction reveals clear mechanical features of cells and organoids by using AFM
Applied Physics Express | 27 August
Kobayashi et al. proposed a method to statistically analyze stiffness distribution in indentation depth direction from multiple force curves measured by AFM.
Kobayashi N, Togo S, Matsuzaki T, Hashiseko K, Kawamura R, Suganuma M, Nakabayashi S, Yoneyama Y, Ouchi R, Takebe T, Yoshikawa H
Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
Nature Communications | 27 August
Han et al. identified unexpected diversity in mesoderm-derivatives during early foregut organogenesis. This study is highly collaborative work with Aaron Zorn group and Mitsuru Morimoto group at RIKEN.
Lu Han, Praneet Chaturvedi, Keishi Kishimoto, Hiroyuki Koike, Talia Nasr, Kentaro Iwasawa, Kirsten Giesbrecht, Phillip C Witcher, Alexandra Eicher, Lauren Haines, Yarim Lee, John M Shannon, Mitsuru Morimoto, James M Wells, Takanori Takebe, Aaron M Zorn
Waiting Time Analysis at University Hospitals Based on Visitor Psychology
International Conference on Human-Computer Interaction | 19 July
Shigeyoshi Iizuka, Shozo Nishii, Eriko Tanimoto, Hiro Nakazawa, Asuka Kodaka, Takanori Takebe
Generation of multi-cellular human liver organoids from pluripotent stem cells
Methods in Cell Biology | 22 May
Wendy elaborated a human liver organoid culture protocol based on Ouchi et al. Cell Metabolism paper in 2019.
Wendy L. Thompson, Takanori Takebe
Orthotopic foetal lung tissue direct injection into lung showed a preventive effect against paraquat-induced acute lung injury in mice
European Journal of Cardio-Thoracic Surgery | 07 April
Okabe et al., in collaboration with thoracic surgeons at Kyoto, extended fetal organ bud transplantation approach towards acute lung injury protection in mouse model.
Ryo Okabe, Toyofumi F Chen-Yoshikawa, Akihiko Yoshizawa, Tsuyoshi Hirashima, Masao Saito, Hiroshi Date, Takanori Takebe
2019
The beta-catenin/YAP signaling axis is a key regulator of melanoma-associated fibroblasts
Signal transduction and targeted therapy | 24 December
T Liu, L Zhou, K Yang, K Iwasawa, AL Kadekaro, T Takebe, T Andl, Y Zhang.
De Novo-Designed Near-Infrared Nanoaggregates for Super-Resolution Monitoring of Lysosomes in Cells, in Whole Organoids and In Vivo
ACS Nano | 04 December
Fang et al. designed a low-toxicity, photostable, near-infrared small molecule fluorescence probe HD-Br for use in the super-resolution imaging of lysosomes.
Fang, H., Yao, S., Chen,Q., Liu, C., Cai, Y., Geng, S., Bai, Y., Tian, Z., Zacharias, A. L., Takebe, T., Chen, Y., Guo, Z., He, W., and Diao, J.
Modelling human hepato-biliary-pancreatic organogenesis from the foregut–midgut boundary
Nature | 25 September
Koike et al. established a multi-organ connection in human stem cell derived organoid model amongst liver, biliary, pancreatic and duodenal tissues.
Koike, H., Iwasawa, K., Ouchi, R., Maezawa, M., Giesbrecht, K., Saiki, N., Ferguson A., Kimura, M., Thompson, W., Wells, J. M., Zorn, A. M. & Takebe, T.
Modeling Steatohepatitis in Humans with Pluripotent Stem Cell-Derived Organoids
Cell Metabolism | 30 May
Ouchi et al. established a method to generate multicellular organoid models of inflammation and fibrosis that can be used for genetic steatohepatitis modeling.
Ouchi, R., Togo, S., Kimura, M., Shinozawa, T., Koido, M., Koike, H., Thompson, W., Karns, R. A., Mayhew, C. N., McGrath, P. S., McCauley, H. A., Zhang, R. R., Lewis, K., Hakozaki, S., Ferguson, A., Saiki, N., Yoneyama, Y., Takeuchi, I., Mabuchi, Y., Akazawa, C., Yoshikawa, H. Y., Wells, J. M., Takebe, T.*
Featured in Nature Reviews
Featured in NIH Director’s Blog
2018
Defining Lineage-Specific Membrane Fluidity Signatures that Regulate Adhesion Kinetics
Stem Cell Reports | 09 October
Takahisa Matsuzaki, Shinya Matsumoto, Toshiharu Kasai, Hiroshi Y. Yoshikawa, Hideki Taniguchi, Takanori Takebe
Optimal Hypoxia Regulates Human iPSC-Derived Liver Bud Differentiation through Intercellular TGFB Signaling
Stem Cell Reports | 01 September
Hiroaki Ayabe, Takahisa Anada, Takuo Kamoya, Tomoya Sato, Masaki Kimura, Emi Yoshizawa, Shunyuu Kikuchi, Yasuharu Ueno, Keisuke Sekine, Gray Camp, Barbara Treutlein, Autumn Ferguson, Osamu Suzuki, Takanori Takebe, Hideki Taniguchi
Digitalized Human Organoid for Wireless Phenotyping
iScience | 31 May
Masaki Kimura, Momoko Azuma, Ran-Ran Zhang, Wendy Thompson, Christopher N. Mayhew, Takanori Takebe
Self-Condensation Culture Enables Vascularization of Tissue Fragments for Efficient Therapeutic Transplantation
Cell Reports | 08 May
Selected as cover article
Yoshinobu Takahashi, Keisuke Sekine, Tatsuya Kin, Takanori Takebe, Hideki Taniguchi
Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids
Stem Cell Reports | 13 March
Ran-Ran Zhang, Masaru Koido, Tomomi Tadokoro, Rie Ouchi, Tatsuya Matsuno, Yasuharu Ueno, Keisuke Sekine, Takanori Takebe, Hideki Taniguchi
2017
Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells
Cell Reports | 05 December
Takanori Takebe, Keisuke Sekine, Masaki Kimura, Satoshi Okamoto, Yasuharu Ueno, Hideki Taniguchi
Synergistic Engineering: Organoids Meet Organs-on-a-Chip
Cell Stem Cell | 07 September
Takanori Takebe, Boyang Zhang, Milica Radisic
Multilineage communication regulates human liver bud development from pluripotency
Nature | 14 June
Featured in Science
Featured in Cell Systems
J. Gray Camp, Keisuke Sekine, Tobias Gerber, Henry Loeffler-Wirth, Hans Binder, Malgorzata Gac, Sabina Kanton, Jorge Kageyama, Georg Damm, Daniel Seehofer, Lenka Belicova, Marc Bickle, Rico Barsacchi, Ryo Okuda, Emi Yoshizawa, Masaki Kimura, Hiroaki Ayabe, Hideki Taniguchi, Takanori Takebe & Barbara Treutlein
Advances in Organoid Technology: Hans Clevers, Madeline Lancaster, and Takanori Takebe
Cell Stem Cell, Q&A | 01 June
Hans Clevers, Madeline Lancaster, and Takanori Takebe
Nutritional modulation of mouse and human liver bud growth through a branched-chain amino acid metabolism
Development | 14 March
Hiroyuki Koike, Ran-Ran Zhang, Yasuharu Ueno, Keisuke Sekine, Yun-Wen Zheng, Takanori Takebe, Hideki Taniguchi
2016
Reverse engineering liver buds through self-driven condensation and organization towards medical application
Developmental Biology | 15 December
Tadahiro Shinozawa, Hiroshi Y. Yoshikaw, Takanori Takebe
Growing Mini‐Organs from Stem Cells
Reviews in Cell Biology and Molecular Medicine | 01 November
Hiroyuki Koike, Tamir Rashid, Takanori Takebe
Autotransplantation of Monkey Ear Perichondrium-Derived Progenitor Cells for Cartilage Reconstruction
Cell Transplantation | 01 May
Shintaro Kagimoto, Takanori Takebe, Shinji Kobayashi, Yuichiro Yabuki, Ayaka Hori, Koichi Hirotomi, Taro Mikami, Toshimasa Uemura, Jiro Maegawa, Hideki Taniguchi
Generating Mini-Organs in Culture
Current Pathobiology Reports | 11 April
Hiroyuki Koike & Takanori Takebe
Engineering pancreatic tissues from stem cells towards therapy
Regenerative Therapy | 01 March
Yoshinobu Takahashi, Takanori Takebe, Hideki Taniguchi
2015
The boom in mini stomachs, brains, breasts, kidneys and more
Nature, News Feature | 29 July
Cassandra Willyard
Vascularized and Complex Organ Buds from Diverse Tissues via Mesenchymal Cell-Driven Condensation
Cell Stem Cell | 07 May
Selected as Cover Article Best of Cell Stem Cell, 2015 News and Views in Cell Stem Cell Featured in Nature Methods
TakanoriTakebe, Masahiro Enomura, Emi Yoshizawa, Masaki Kimura, Hiroyuki Koike, Yasuharu Ueno, Takahisa Matsuzaki, Takashi Yamazaki, Takafumi Toyohara, Kenji Osafune, Hiromitsu Nakauchi, Hiroshi Y.Yoshikawa, Hideki Taniguchi
2014
Transient vascularization of transplanted human adult–derived progenitors promotes self-organizing cartilage
Journal of Clinical Investigation | 09 September
Takanori Takebe, Shinji Kobayashi, Hiromu Suzuki, Mitsuru Mizuno, Yu-Min Chang, Emi Yoshizawa, Masaki Kimura, Ayaka Hori, Jun Asano, Jiro Maegawa, and Hideki Taniguchi
Novel strategies for liver therapy using stem cells
Stem Cells and Development | 02 September
Rashid T, Takebe T, Nakauchi H.
Brief Report: Reconstruction of Joint Hyaline Cartilage by Autologous Progenitor Cells Derived from Ear Elastic Cartilage
STEM CELLS | 23 August
Mitsuru Mizuno, Shinji Kobayashi, Takanori Takebe, Hiroomi Kan, Yuichiro Yabuki, Takahisa Matsuzaki, Hiroshi Y. Yoshikawa, Seiichiro Nakabayashi, Lee Jeong Ik, Jiro Maegawa, Hideki Taniguchi
Generation of pancreatic beta-cells from pluripotent stem cells
Organ Biology | 10 July
Yoshinobu Takahashi, Takanori Takebe, Hideki Taniguchi.
The CD133 + CD44 + Precancerous Subpopulation of Oval Cells Is a Therapeutic Target for Hepatocellular Carcinoma
Stem Cells and Development | 26 June
Yun-Wen Zheng, Tomonori Tsuchida, Taiki Shimao, Bin Li, Takanori Takebe, Ran-Ran Zhang, Yu Sakurai, Yasuharu Ueno, Keisuke Sekine, Naoto Ishibashi, Makiko Imajima, Takuji Tanaka, and Hideki Taniguchi
Human iPSC‐Derived Miniature Organs: A Tool for Drug Studies
Clinical Pharmacology & Therapeutics | 21 March
T Takebe, H Taniguchi.
Engineering of human hepatic tissue with functional vascular networks
Organogenesis | 22 February
Takanori Takebe, Naoto Koike, Keisuke Sekine, Ryoji Fujiwara, Takeru Amiya, Yun-Wen Zheng & Hideki Taniguchi
Ring1B promotes hepatic stem/progenitor cell expansion through simultaneous suppression of Cdkn1a and Cdkn2a in mice
Hepatology | 04 February
Hiroyuki Koike, Yasuharu Ueno, Takako Naito, Tomoya Shiina, Susumu Nakata, Rie Ouchi, Yuta Obana, Keisuke Sekine, Yun‐Wen Zheng, Takanori Takebe, Kyo‐ichi Isono, Haruhiko Koseki, Hideki Taniguchi
Generation of a vascularized and functional human liver from an iPSC-derived organ bud transplant
Nature Protocols | 23 January
Takanori Takebe, Ran-Ran Zhang, Hiroyuki Koike, Masaki Kimura, Emi Yoshizawa, Masahiro Enomura, Naoto Koike, Keisuke Sekine & Hideki Taniguchi
Vascularized and functional liver devided from human induced pluripotent stem cells by recapitulating organogenesis
Yokohama Medical Journal | 01 January
T. Takebe, H. Taniguchi.
2013
Creation of vascularized and functional organ from human iPS cell
Organ Biology | 10 July
Takanori Takebe, Hideki Taniguchi.
Vascularized and functional human liver from an iPSC-derived organ bud transplant
Press in BBC, The Economist, Scientific American, The Guardian, etc… | 03 July
Selected as Breakthrough of the Year, 2013 in Science
Takanori Takebe, Keisuke Sekine, Masahiro Enomura, Hiroyuki Koike, Masaki Kimura, Takunori Ogaeri, Ran-Ran Zhang, Yasuharu Ueno, Yun-Wen Zheng, Naoto Koike, Shinsuke Aoyama, Yasuhisa Adachi & Hideki Taniguchi
Selected as World top 5 discovery in Discover magazineNews and Views in NatureFeatured in Science, Nature Medicine, Cell Stem Cell, Hepatology, Gastroenterology, Cell Research, etc…
The generation of pancreatic β-cell spheroids in a simulated microgravity culture system
Biomaterials | 01 July
Hiroyasu Tanaka, Shin Tanaka, Keisuke Sekine, Sayaka Kita, Ai Okamura, Takanori Takebe, Yun-Wen Zheng, Yasuharu Ueno, Junzo Tanaka, Hideki Taniguchi
2012
Establishment of automated culture system for murine induced pluripotent stem cells
BMC Biotechnology | 01 November
Hiroyuki Koike, Koji Kubota, Keisuke Sekine, Takanori Takebe, Rie Ouchi, Yun-Wen Zheng, Yasuharu Ueno, Naoki Tanigawa, Hideki Taniguchi
Generation of Functional Human Vascular Network
Transplantation Proceedings | 01 July
T Takebe, N Koike, K Sekine, M Enomura, Y Chiba, Y Ueno, Y-W Zheng, H Taniguchi
Self-organization of Human Hepatic Organoid by Recapitulating Organogenesis in Vitro
Transplantation Proceedings | 01 May
T Takebe, K Sekine, Y Suzuki, M Enomura, S Tanaka, Y Ueno, Y-W Zheng, H Taniguchi
2011
Presence of Cartilage Stem/Progenitor Cells in Adult Mice Auricular Perichondrium
PLOS ONE | 19 October
Shinji Kobayashi ,Takanori Takebe ,Yun-Wen Zheng,Mitsuru Mizuno,Yuichiro Yabuki,Jiro Maegawa,Hideki Taniguchi
Reconstruction of human elastic cartilage by a CD44+ CD90+ stem cell in the ear perichondrium
PNAS | 30 August
Shinji Kobayashi, Takanori Takebe, Midori Inui, Sayaka Iwai, Hiroomi Kan, Yun-Wen Zheng, Jiro Maegawa, and Hideki Taniguchi
Reconstruction of human elastic cartilage by a CD44+ CD90+ stem cell in the ear perichondrium
PNAS | 30 August
Shinji Kobayashi, Takanori Takebe, Midori Inui, Sayaka Iwai, Hiroomi Kan, Yun-Wen Zheng, Jiro Maegawa, and Hideki Taniguchi
REVIEW
2024
Organoid-guided precision hepatology for metabolic liver disease
Journal of Hepatology | 17 January
In this review, Taka and Sho outline current research efforts focused on integrating multiple synthetic tissue models of key metabolic organs, with an emphasis on organoid-based systems.
Sho Osonoi, Takanori Takebe
Narrative engineering of the liver
Current Opinion in Genetics & Development | 01 August
Lee and Takebe discuss advancements in liver organoid technology through the lens of ‘narrative engineering’ in an attempt to synergize evolving understanding around molecular and cellular landscape governing hepatogenesis with engineering-inspired approaches for organoidgenesis in this review.
Inkyu S Lee, Takanori Takebe
Organoids by design
Science | 01 June
Discussed current and future of designing complex organoids.
Takanori Takebe*, James M. Wells
BOOK
Experimental Medicine extra issue
Yodosha Co., Ltd. ISBN 978-4-7581-2239-9 | 26 March
Takanori Takebe . Japan
Encyclopedia of Molecular Cell Biology and Molecular Medicine
Growing Mini-Organs from Stem Cells. Wiley-VCH. Volume 2 Issue 4. | 01 November
Koike H, Takebe T*
Hyper Bio Assembler for 3D Cellular Systems
‘The Visualization of Human Organogenesis from Stem Cells by Recapitulating Multicellular Interactions’, p. 275-283, 15 | 01 July
Ran-Ran Zhang, Hiroyuki Koike, Takanori Takebe
FEATURED
Anniversary reflections: Inspiring discoveries and the future of the field
Cell Stem Cell | 02 June
Lancaster M, Morris S, Takebe T, Qian L, Gao S, Huch M